In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation
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چکیده
منابع مشابه
in silico designing of a new cysteine analogue of hirudin variant 3 for site specific pegylation
hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. recombinant hirudin (r-hir) displays certain drawbacks including bleeding and immunogenicity. to solve these problems, cysteine-specific pegylation has been proposed as a successful technique. however, proper selection of the appropriate cysteine residue for substitution is a critical step. this study has, for the ...
متن کاملIn silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation
Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection of the appropriate cysteine residue for substitution is a critical step. This study has, for the ...
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ژورنال
عنوان ژورنال: Research in Pharmaceutical Sciences
سال: 2017
ISSN: 1735-5362
DOI: 10.4103/1735-5362.199048